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Low-Intensity Focused Ultrasound Pulsation (LIFUP) / Deep Brain Stimulation / Amnestic Mild Cognitive Disorder · Interventional Study
ClinicalTrials.gov · August 19, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a clinical trial registry record documenting an active but unreported study of low-intensity focused ultrasound targeting the entorhinal cortex in mild cognitive impairment and mild Alzheimer's disease. The study measures short-term neuroimaging biomarkers (perfusion and functional connectivity on fMRI at 40 minutes) and memory tests, but results are not yet posted and no evidence of efficacy exists in this source.
Interventional, Randomized, Parallel, Double masking, Treatment purpose. Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease; age from 50 Years; to 90 Years. Intervention: LIFUP Dose Group 1; LIFUP Dose Group 2; LIFUP Dose Group 3. Compared with: Sham LIFUP — Sham Comparator. n = 120. 1 site: United States.
This is a clinical trial registry record documenting an active but unreported study of low-intensity focused ultrasound targeting the entorhinal cortex in mild cognitive impairment and mild Alzheimer's disease. The study measures short-term neuroimaging biomarkers (perfusion and functional connectivity on fMRI at 40 minutes) and memory tests, but results are not yet posted and no evidence of efficacy exists in this source.
Results not yet reported in this registry record; no efficacy or safety data available
This registry record documents a planned investigation only. Clinicians should await published results before considering low-intensity focused ultrasound for cognitive impairment. The short follow-up window (40 minutes) and surrogate neuroimaging outcomes limit direct clinical applicability.
This is a registry record of an active interventional study with neuroimaging surrogate endpoints in a small population; no results are reported, limiting evidence strength.
As stated by the source record.
Quoted from the source exactly as published.
This registry record documents a planned investigation only. Clinicians should await published results before considering low-intensity focused ultrasound for cognitive impairment. The short follow-up window (40 minutes) and surrogate neuroimaging outcomes limit direct clinical applicability.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT05417555). This is a study registration, not published results. Lead sponsor: University of California, Los Angeles. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 120 participants (ACTUAL). Conditions: Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease. Interventions: DEVICE: Low-Intensity Focused Ultrasound Pulsation (LIFUP). Primary outcome measures: Change in Perfusion Arterial Spin Labeling (ASL) fMRI Signal throughout Brain , 40 minutes; Changes in BOLD-related functional connectivity from baseline in fMRI brain scan to 40 minutes. , 40 minutes. Brief summary: The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease. The main questions the study seeks to answer are: 1. Can LIFUP increase brain activity in the targeted area? 2. Can LIFUP improve memory in people with MCI and mild AD? 3. Can LIFUP improve connectivity of memory networks in the brain? Participants in this study will complete MRIs and memory testing, and receive Low Intensity Focused Ultrasound to a part of their brain involved in memory (the entorhinal cortex).
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.