Loading
Life sciences · Journal article
Quality in Sport · September 17, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Introduction. Hypercholesterolemia is typically associated with obesity and metabolic syndrome, yet elevated total and LDL cholesterol are also frequently observed in underweight individuals, including patients with anorexia nervosa (AN). This paradox can cause diagnostic uncertainty when lipid results are interpreted based on concepts derived from obesity-related dyslipidemia. Aim. To summarize current evidence on mechanisms underlying hypercholesterolemia in underweight individuals, with emphasis on AN, and to outline its clinical significance and management. Materials and Methods. A narrative review of PubMed and Google Scholar literature published up to July 2026, prioritizing systematic reviews, meta-analyses, and observational studies on lipid abnormalities in underweight populations. Results. Hypercholesterolemia in starvation states arises from reduced hepatic LDL-receptor activity, a low-T3 endocrine state, altered cortisol, insulin and leptin signalling, impaired bile acid synthesis, and altered lipoprotein transport, rather than dietary cholesterol intake. These adaptations differ from obesity-driven dyslipidemia and generally improve with nutritional rehabilitation. Conclusions. Hypercholesterolemia associated with underweight is usually a reversible metabolic adaptation to prolonged energy deficiency. Nutritional rehabilitation should be the primary treatment strategy, whereas persistent lipid abnormalities after weight restoration require further diagnostic evaluation.