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Life sciences · Interventional Study
ClinicalTrials.gov · September 15, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07718178). This is a study registration, not published results. Lead sponsor: Cairo University. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 60 participants (ESTIMATED). Conditions: Central Obesity, Ventilatory Function. Interventions: PROCEDURE: Mulligan Thoracic Mobilization; BEHAVIORAL: low carbohydrate; BEHAVIORAL: Aerobic Exercise. Primary outcome measures: Forced Vital Capacity , Baseline (pre-intervention) and at the end of the 8-week training period (post-intervention).; Forced Expiratory Volume in One Second , Baseline (pre-intervention) and at the end of the 8-week training period (post-intervention).; Ratio of Forced Expiratory Volume in One Second to Forced Vital Capacity , Baseline (pre-intervention) and at the end of the 8-week training period (post-intervention).; Maximum Voluntary Ventilation , Baseline (pre-intervention) and at the end of the 8-week training period (post-intervention).; Chest Wall Expansion at the Fourth Intercostal Space , Baseline (pre-intervention) and at the end of the 8-week training period (post-intervention).; Chest Wall Expansion at the Xiphoid Process Level , Baseline (pre-intervention) and at the end of the 8-week training period (post-intervention).. Brief summary: The goal of this clinical trial is to learn whether Mulligan thoracic mobilization in extension improves ventilatory functions and chest wall expansion in adults with central obesity. It will also evaluate whether adding Mulligan thoracic mobilization to a low-carbohydrate diet and aerobic exercise provides greater benefits than diet and exercise alone. The main questions it aims to answer are: Does Mulligan thoracic mobilization improve ventilatory functions (FVC, FEV₁, FEV₁/FVC ratio, and MVV) in adults with central obesity? Does Mulligan thoracic mobilization improve chest wall expansion, functional capacity, and health-related quality of life? Researchers will compare Mulligan thoracic mobilization combined with a low-carbohydrate diet and aerobic exercise to a low-carbohydrate diet and aerobic exercise alone to determine whether the addition of thoracic mobilization improves respiratory outcomes. Participants will: Be randomly assigned to either the intervention group or the control group. Receive an individualized low-carbohydrate diet and supervised aerobic exercise for 8 weeks. Receive Mulligan thoracic mobilization in extension three times per week for 8 weeks if assigned to the intervention group. Undergo assessments of ventilatory functions, chest wall expansion, functional capacity, and quality of life before and after the intervention.