Loading
Life sciences · Interventional Study
ClinicalTrials.gov · November 2, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Interventional Study.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07910786). This is a study registration, not published results. Lead sponsor: University Hospital, Ghent. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 23 participants (ACTUAL). Conditions: Sepsis, Peritonitis; Acute. Interventions: PROCEDURE: Liver biopsy; PROCEDURE: blood sampling. Primary outcome measures: To study whether septic peritonitis patients have alterations in the expression levels of inflammatory genes linked to reduced activity of GR and PPARa in liver tissue. , Day 0; To study whether human sepsis liver samples show an accumulation of FFA and alterations in collagen in liver. , Day 0; To study whether there are indications for reduced activity of GR and PPARa in blood plasma. , up to day 7; To study whether there is a correlation between reduced GR/PPARa activity in the liver during sepsis and the general status of the septic patient (SOFA score), inflammatory markers such as IL6, TNF, procalcitonin, corticosterone or other metabolites. , up to day 30; To study whether septic peritonitis patients have alterations in the expression levels of metabolic genes linked to reduced activity of GR and PPARa in liver tissue. , Day 0. Brief summary: The aim of this study is to evaluate the activity status of two highly essential transcription factors (GR and PPARa), which are of crucial importance in the successful metabolic rearrangements (gluconeogenesis and fatty acid beta oxidation respectively) during sepsis, but which appear to lose their activity in a mouse model of septic peritonitis. Since these metabolic activities are located in liver, the activity status of these factors will be studied in livers of septic peritonitis patients and control patients, and will be related to metabolites in blood and to the disease status of these patients.