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Life sciences · Preprint
arXiv · November 6, 2026
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Intracranial EEG provides high signal-to-noise ratio and spatial resolution for detecting epileptic activity, but patient-specific electrode placement leads to substantial variation in channel count and montage across subjects. This heterogeneity limits the generalization of existing detectors under subject-independent evaluation. We propose MOSAIC (MOntage-agnostic Self-distilled Adaptive Inter-channel Connectivity learning), a lightweight graph-learning framework for subject-independent iEEG seizure detection. MOSAIC pairs a shared convolutional channel encoder with a patient-agnostic channel-attention module that infers a weighted inter-channel adjacency matrix from the encoded features, requiring no fixed montage graph. An exponential moving average self-distillation objective regularizes each prediction toward a slowly updated per-patient teacher. Across four public iEEG corpora (SWEC-ETHZ long- and short-term, Mayo, FNUSA), MOSAIC outperforms state-of-the-art baselines in F2 and Cohen's $κ$ while learning more stable inter-channel adjacencies, demonstrating that self-distilled connectivity learning transfers across unseen implantations.