Life sciences · Preprint
arXiv · September 10, 2026
Raises a question worth testing. It does not answer one.
This is a computational methods paper proposing a reinforcement learning framework combined with reflex-based neuromuscular control to simulate muscle-driven human locomotion. The work is purely algorithmic, with outputs evaluated only against simulation metrics; it contains no empirical validation in living subjects and does not yet constitute evidence for clinical or physiological claims.
Preprint. Intervention: Reflex-Informed Neuromuscular Reinforcement Learning framework combining fixed phase-dependent reflex controller with reinforcement learning policy to modulate reflex gains and thresholds.
Framework generates physiologically plausible locomotion with improved kinematic accuracy and dynamic consistency under nominal walking conditions Learned policy remains robust under simulated muscle weakness and external perturbations without retraining Better bilateral symmetry and stride-to-stride consistency reported in simulation outputs
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The source did not state who this applies to in practice.
This is a computational modelling and algorithm development study with no experimental validation in humans or animals, presenting a novel framework concept without clinical or biological outcome data.
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Muscle-driven locomotion provides a physically grounded approach to generating realistic human movement. However, achieving both physiological plausibility and adaptability to changes in musculoskeletal capacity and external disturbances remains a fundamental challenge. To address this limitation, we propose a Reflex-Informed Neuromuscular Reinforcement Learning framework for muscle-driven locomotion. Within this framework, a fixed phase-dependent reflex controller serves as the underlying neuromuscular control mechanism, while the reinforcement learning policy produces four biomechanically meaningful residual parameters to modulate key reflex gains and thresholds associated with hip swing, knee support, and ankle propulsion according to the current state. Experimental results demonstrate that the proposed framework generates physiologically plausible locomotion with improved kinematic accuracy and dynamic consistency, as well as better bilateral symmetry and stride-to-stride consistency under nominal walking conditions. The learned policy remains robust under muscle weakness and external perturbations without retraining.
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