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Life sciences · Interventional Study
ClinicalTrials.gov · September 18, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06881342). This is a study registration, not published results. Lead sponsor: Global Institute of Human Development. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 137 participants (ACTUAL). Conditions: Depression, Anxiety, Distress, Emotional, Psychosocial Problem, Functioning, Psychosocial. Interventions: BEHAVIORAL: Enhanced School Mental Health Program (eSMHP). Primary outcome measures: Patient Health Questionnaire (PHQ-9) for adolescents , Enrollment, and 6 weeks and 3-months from baseline. Brief summary: This study aims to explore effective ways to reduce depressive symptoms in adolescents through two school-based interventions. This study examines whether the Enhanced School Mental Health Program (eSMHP) Plus, delivered by teachers and non-specialists, can serve as a first-line intervention to reduce psychosocial distress-an intermediate outcome that must be addressed to lower the risk of depression (primary outcome) in adolescents. For those who do not respond to eSMHP Plus, the study investigates if a Cognitive Behavioural Therapy (CBT) based guided self-help app could be an effective step-up or second-level intervention. Researchers will assess the feasibility and acceptability of these approaches among 200 adolescents (aged 13-15) from 8 public schools in Rawalpindi, Pakistan. Findings will guide future large-scale studies and strategies for personalised mental health care for adolescents in low-resource settings.