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Life sciences · Journal article
One Health · August 1, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a cross-sectional genomic characterization of 78 S. Dublin isolates from cattle, dogs, and humans in Florida (2019–2024) that documents widespread multidrug resistance genes, conserved virulence factors, and phylogenetic evidence of close genetic relatedness across host species. The study provides descriptive microbiological intelligence on AMR patterns and potential for cross-species transmission but does not establish causation, clinical impact, or epidemiological links.
Retrospective cross-sectional genomic descriptive study. Clinical S. Dublin isolates from dairy cattle, dogs, and humans in Florida, 2019–2024. Eligibility criteria not specified.. Intervention: Comparative genomic analysis (no intervention applied; observational retrospective characterization). n = 78. Florida, USA.
All 78 isolates carried aminoglycoside, tetracycline, and sulfonamide resistance genes (aac(6')-Iaa, aph(6)-Id, tetA, sul2) Beta-lactamase genes (bla TEM variants) were more frequent in human- and dog-derived isolates than cattle-derived isolates Rare bla CMY variants (bla CMY-61, bla CMY-130, bla CMY-153, bla CMY-2b) detected in only one cattle isolate
No data on clinical outcomes, severity, treatment response, or mortality in human or animal cases.
This genomic survey documents high prevalence of multidrug resistance and suggests genomic overlap among S. Dublin in different host species, supporting One Health surveillance and judicious antimicrobial stewardship. However, without epidemiological linkage data, clinical severity outcomes, or transmission validation, the results cannot yet guide specific clinical or public health intervention.
A descriptive genomic survey of 78 clinical isolates with no comparator group, control arm, or hypothesis testing; documents AMR patterns and cross-species relatedness but lacks experimental validation or clinical outcomes.
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Quoted from the source exactly as published.
This genomic survey documents high prevalence of multidrug resistance and suggests genomic overlap among S. Dublin in different host species, supporting One Health surveillance and judicious antimicrobial stewardship. However, without epidemiological linkage data, clinical severity outcomes, or transmission validation, the results cannot yet guide specific clinical or public health intervention.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Salmonella enterica serovar Dublin (S. Dublin) is a cattle-adapted pathogen that can cause severe systemic infections in humans and animals. Understanding genomic relatedness across host species is essential for assessing the zoonotic potential and dissemination of antimicrobial resistance (AMR). In this study, 78 clinical S. Dublin strains, isolated in Florida between 2019 and 2024, were subjected to comparative genomic analysis. These included 19 animal-derived isolates (17 from dairy cattle and two from dogs) and 59 human-derived isolates. AMR gene profiling revealed widespread multidrug resistance, with genes conferring resistance to aminoglycoside (aac(6')-Iaa, aph(6)-Id), tetracycline (tetA), and sulfonamide (sul2) detected in all isolates. Beta-lactamase genes, particularly bla TEM variants, were detected more frequently in human- and dog-derived isolates than in cattle-derived isolates. In contrast, rare bla CMY variants (bla CMY-61, bla CMY-130, bla CMY-153, and bla CMY-2b) were detected in only one cattle isolate. Plasmid analysis revealed that IncX1, IncFII(S), and IncC replicons were common among the isolates, highlighting their potential role in facilitating AMR dissemination via horizontal gene transfer. Virulence gene profiling revealed conserved Salmonella pathogenicity islands, type III and type VI secretion systems, and the spv operon across S. Dublin isolates from all host species. Multilocus sequence typing (MLST) confirmed that all isolates belonged to sequence type (ST) 10, and most harbored the Gifsy-2 prophage. The SNP-based phylogeny revealed distinct host-associated clades as well as mixed-host clusters, demonstrating close genomic relatedness among isolates from different host species and suggesting possible cross-species transmission, exposure to shared sources, or circulation of closely related lineages. These findings illustrate the interconnectedness of animal and human S. Dublin infections, emphasize the importance of responsible antimicrobial use, and highlight the value of genomic surveillance for detecting and controlling S. Dublin infections. Collectively, this study provides a genomic framework for assessing cross-species relatedness, virulence characteristics, and AMR patterns of S. Dublin.
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