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Life sciences · Journal article
Профилактическая Медицина И Здоровье · October 3, 2026
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Given the growing interest in natural polyphenols, which exhibit a broad spectrum of biological effects and have potential applications in the prevention and treatment of various diseases, increasing attention has been devoted to investigating their pharmacological activity. Apigenin, a naturally occurring flavonoid found in numerous medicinal plants, has attracted considerable interest because of its wide range of pharmacological properties, including potential antitumor activity. Recent studies indicate that apigenin can inhibit breast cancer cell proliferation, induce apoptosis, and suppress angiogenesis and metastasis by modulating various signaling pathways and cell-cycle regulators. This review examines the phytochemical characteristics of apigenin, its pharmacokinetic properties, and the principal mechanisms underlying its antitumor effects. Current limitations and prospects for the development of apigenin-based therapeutics are also discussed. The available evidence suggests that apigenin is a promising compound for further investigation in the development of novel approaches to breast cancer therapy. However, additional preclinical and clinical studies are required to confirm its efficacy and safety.