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Life sciences · Observational Study
ClinicalTrials.gov · October 23, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT06571175). This is a study registration, not published results. Lead sponsor: Norwegian University of Science and Technology. Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 79 participants (ACTUAL). Conditions: Aortic Valve Stenosis, Myocardial Fibrosis. Interventions: DIAGNOSTIC_TEST: High frame rate echocardiography; DIAGNOSTIC_TEST: MRI; DIAGNOSTIC_TEST: Blood test; DIAGNOSTIC_TEST: ECG and Holter-ECG; DIAGNOSTIC_TEST: 6 min walking test. Primary outcome measures: Cardiovascular morbidity , 5 year; Cardiovascular mortality , 5 year. Brief summary: This study is a long term follow-up of patients that were included as part of a previous study (NCT03422770), where patients with aortic stenosis and healthy controls went through echocardiography, cardiac MRI, long-term ECG-recording, blood tests and quality of life assessment. Echocardiography included high frame ultrasound for detection of natural mechanical waves, and the measured speed of these waves were used as a marker of the extent of myocardial fibrosis. Up to five years have now passed since inclusion at baseline, and a proportion of the patients in the cohort have undergone aortic valve replacement at some point. In this study, the investigators will repeat the cardiac imaging (echocardiography and cardiac MRI), ECG and blood test, to assess long-term changes in myocardial fibrosis in aortic stenosis patients.