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Life sciences · Observational Study
ClinicalTrials.gov · October 29, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT06904365). This is a study registration, not published results. Lead sponsor: Washington University School of Medicine. Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 11 participants (ACTUAL). Conditions: Uterine Cancer, Rectal Cancer, Colon Cancer, Breast Cancer, Lung Cancer, Sarcoma, Cervix Cancer, Head and Neck Cancer, Anal Cancer, Liver Cancer, Gastric Cancer, Bladder Cancer. Interventions: DEVICE: HyperSight cone beam computed tomography (CBCT) scan; DEVICE: ETHOS 2.0. Primary outcome measures: Incidence of ovarian visualization , Estimated to be 5 days. Brief summary: Female patients with early onset (\<50 years old) pelvic malignancies such as uterine and rectal cancers are rising in incidence, which often requires pelvic radiation; many of these patients are premenopausal and at a high risk of premature ovarian failure from radiotherapy. Premature ovarian failure carries significant cardiac, musculoskeletal, sexual, and psychosocial morbidity. Ovarian transposition carries variable success rates, is not readily accessible to the general population, and can still be at risk of clinically significant radiotherapy doses. There is an unmet need for innovative techniques to protect ovarian function.