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Life sciences · Journal article
Northern Clinics of Istanbul · September 16, 2026
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D egenerative osteoarthritis (OA) is the most com- mon cause of chronic knee pain [1].The global prevalence of knee OA is reported to be 16% in individuals aged 15 and over, and 22.9% in those aged 40 and over [2].Due to an aging population and rising obesity rates, the number of individuals affected by symptomatic knee OA is projected to increase significantly [3].The pathogenesis of OA is multifactorial and involves biome-chanical, inflammatory, and metabolic processes.These mechanisms contribute to cartilage damage, synovitis, and various subchondral bone abnormalities [4].This condition, characterized by the progressive degradation of articular cartilage, primarily results in pain, activity limitations, and reduced mobility [5].Beyond physical impairment, it also restricts social participation and negatively affects overall quality of life [6].