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Life sciences · Journal article
Journal of Diabetes and Metabolic Disorders · August 14, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a descriptive epidemiological report documenting a 188% rise in age-adjusted mortality rates involving cardiac arrest and obesity from 1999 to 2023 in the United States, with significant disparities by sex, race/ethnicity, age, geography, and rurality. The analysis establishes a public health trend but does not establish causation, intervention efficacy, or mechanisms. Clinicians and policy-makers should note the rising burden as motivation for prevention research and targeted public health efforts, but the evidence does not directly change clinical practice.
Retrospective trend analysis of national mortality registry data. US deaths involving both cardiac arrest (ICD-10 I46) and obesity (ICD-10 E66) in adults aged 25 years or older, 1999–2023.. n = 128,550. United States, stratified by geographic region (West, Midwest, and other regions) and rurality (rural vs. urban)..
Age-adjusted mortality rate rose from 11.3 per million in 1999 to 32.5 per million in 2023 (AAPC: 4.45%, 95% CI: 3.72–5.01, p < 0.001) Men had higher mortality rates than women (24.7 vs. 19.5 per million) with steeper increase (AAPC: 5.34%, p < 0.001) Older adults had higher mortality (45.2 per million) than younger adults (7.0 per million)
Study uses ICD-10 codes for both cardiac arrest and obesity; does not establish causal relationship between obesity and cardiac arrest mortality. Age-adjusted mortality rate rose from 11.3 per million in 1999 to 32.5 per million in 2023 (AAPC: 4.45%, 95% CI: 3.72–5.01, p < 0.001)
This epidemiological trend establishes a substantial and growing public health burden of mortality involving cardiac arrest and obesity. Clinicians should recognize that certain populations—older men, Non-Hispanic Blacks and Whites, rural residents—bear a disproportionate burden, informing targeted risk assessment and prevention efforts; however, the analysis does not directly prescribe changes to acute management or prevention strategies.
A descriptive epidemiological analysis of mortality trends using administrative data; establishes rising burden and disparities but lacks mechanistic insight, intervention, or causal inference.
As stated by the source record.
Quoted from the source exactly as published.
This epidemiological trend establishes a substantial and growing public health burden of mortality involving cardiac arrest and obesity. Clinicians should recognize that certain populations—older men, Non-Hispanic Blacks and Whites, rural residents—bear a disproportionate burden, informing targeted risk assessment and prevention efforts; however, the analysis does not directly prescribe changes to acute management or prevention strategies.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Obesity is a major risk factor for cardiovascular disease, yet its role in cardiac arrest (CA) mortality remains a growing public health concern. This study analyzed disparities in mortality involving CA and obesity by age, sex, race/ethnicity, and geographic region. Age-adjusted mortality rates (AAMRs) per million in adults (25 years or older) were obtained from CDC WONDER using ICD-10 codes for obesity (E66) and CA (I46). Joinpoint regression estimated Annual Percent Change (APC) and Average APC (AAPC), with significance at p < 0.05. Between 1999 and 2023, a total of 128,550 deaths involving CA and obesity, with most deaths in medical facilities (58.8%). The AAMR rose from 11.3 in 1999 to 32.5 in 2023 (AAPC: 4.45%, 95% CI: 3.72-5.01, p < 0.001). Men had higher AAMRs than women (24.7 vs. 19.5) and a steeper increase (AAPC: 5.34%, p < 0.001). Older adults exhibited higher AAMRs (45.2) compared to younger adults (7.0). Among racial groups, Non-Hispanic (NH) Blacks had the highest AAMR (38.4 per million), while NH Whites experienced the most significant rise (AAPC: 4.97%, p < 0.001). The West had the highest regional AAMR (29.0), while the Midwest experienced the steepest increase (AAPC: 5.7%, p < 0.001). Rural areas exhibited higher AAMRs than urban regions, both of which were trending upward. Mortality involving CA and obesity has been rising, with significant disparities in older men, NH Blacks and Whites, those from the West, and rural communities. The increasing burden underscores the need for targeted prevention strategies. The online version contains supplementary material available at 10.1007/s40200-026-02037-9.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.