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Life sciences · Journal article
International Journal of Drug Delivery Technology · October 9, 2026
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Background: Metabolic syndrome (MetS) a cluster of central obesity, insulin resistance, dyslipidaemia and hypertension affects approximately 25% of the global adult population.Conventional management relies on lifestyle modification and polypharmacy, often with limited long-term adherence.Objectives: To synthesise classical Ayurvedic principles with contemporary biomedical evidence for the management of MetS, and to propose an integrated, step-wise treatment algorithm.Methods: A narrative review was conducted by searching classical Ayurvedic texts (Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, Bhaishajya Ratnavali) and modern databases (PubMed, Scopus, Google Scholar) up to December 2025.Only original research, systematic reviews and randomised controlled trials in English were included.Results: Ayurveda views MetS through the lens of Mandagni (weak digestive fire), Ama (metabolic toxins), Medovaha Srotas (fat-carrying channels) and Sthaulya (obesity).This framework maps closely onto modern concepts of insulin resistance, metabolic endotoxaemia and chronic inflammation.Randomised controlled trials and clinical studies demonstrate that dietary modification, Panchakarma (especially Virechana and Lekhana Basti), and formulations such as Triphala, Guggulu, Tryushnadi Churna and Chandraprabha Vati significantly improve body weight, lipid profiles, glycaemic control and inflammatory markers.Mechanistic studies show prebiotic modulation of gut microbiota, upregulation of mitochondrial biogenesis markers (PGC-1α, TFAM) and downregulation of inflammasome pathways (NLRP3, caspase-1).Conclusion: Ayurvedic interventions offer a rational, multi-targeted approach for MetS that addresses both root causes and clinical manifestations.An integrated step-wise algorithm is proposed.High-quality randomised controlled trials and multi-omic mechanistic studies are needed for full validation.