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Life sciences · Observational Study
ClinicalTrials.gov · November 2, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Observational Study.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
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Registry record from ClinicalTrials.gov (NCT04325529). This is a study registration, not published results. Lead sponsor: Mclean Hospital. Recruitment status: ACTIVE_NOT_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 148 participants (ACTUAL). Conditions: Major Depression in Remission. Interventions: DEVICE: Aversive stimuli. Primary outcome measures: Clinical Interview , Baseline; Behavioral Performance on the Probabilistic Reward Task (PRT) , Baseline; MRI Data , MRI scans take place within 30 days of Screening Visit; Salivary Cortisol , Baseline; Follow-up Clinical interviews , Change from Baseline at 6 months and 12 months after the MRI scanning visit. Brief summary: This study investigates how remitted individuals with past major depressive disorder (MDD) make approach-avoidance decisions and which brain regions are implicated in such decisions. Information collected through MRI and behavioral tasks will be used to predict depressive symptoms in the future.