Life sciences · Interventional Study
ClinicalTrials.gov · November 4, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT04451135). This is a study registration, not published results. Lead sponsor: Washington University School of Medicine. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 31 participants (ACTUAL). Conditions: ECT, Treatment Resistant Depression. Interventions: DIAGNOSTIC_TEST: Electroencephalographic (EEG); DIAGNOSTIC_TEST: Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16); DIAGNOSTIC_TEST: Ictal Electroencephalographic (EEG) Measurements; DIAGNOSTIC_TEST: Post-Ictal Electroencephalographic (EEG) Suppression Measurements. Primary outcome measures: Interval change in Quick Inventory of Depressive Symptomatology-16 Item Self Report (QIDS-SR16) between ECT sessions. , Up to 8 weeks during patients ECT treatment course; Duration of Central Positive Complexes during ECT treatments. , Up to 8 weeks during patients ECT treatment course; Duration of PGES during ECT treatments. , Up to 8 weeks during patients ECT treatment course; Density of EEG sleep spindles during non-rapid eye movement (NREM) stages N2 on evenings following ECT treatments. , Up to 8 weeks during patients ECT treatment course; Slow wave activity (SWA) during N3 sleep on evenings following ECT treatments , Up to 8 weeks during patients ECT treatment course. Brief summary: Single-center study to determine the relationship between changes in depression symptoms and electroencephalographic (EEG) patterns induced by electroconvulsive therapy (ECT)