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Heart Failure · Observational Study
ClinicalTrials.gov · August 4, 2026
Early or partial results. Treat as a signal, not a conclusion.
MAP-HEART is a planned observational cohort study that will enroll 2000 people with heart failure to collect multi-omics biosamples and follow all-cause mortality over 10 years. No results have been reported in this registry record; the study is currently recruiting by invitation.
Observational. Heart Failure; age from 18 Years; to 100 Years. Intervention: Participants with heart condition. n = 2,000. 1 site: United States.
MAP-HEART is a planned observational cohort study that will enroll 2000 people with heart failure to collect multi-omics biosamples and follow all-cause mortality over 10 years. No results have been reported in this registry record; the study is currently recruiting by invitation.
Primary outcome (10-year all-cause mortality) will not be complete for many years.
This study aims to identify blood-based and multi-omics biomarkers associated with long-term mortality in heart failure. Results, when available, may improve risk stratification and understanding of HF progression mechanisms, but clinical use remains investigational pending study completion and validation.
This is a registry record for an ongoing observational study with no results posted; enrollment is by invitation and primary outcomes will not be assessed until 10-year follow-up is complete.
As stated by the source record.
Quoted from the source exactly as published.
This study aims to identify blood-based and multi-omics biomarkers associated with long-term mortality in heart failure. Results, when available, may improve risk stratification and understanding of HF progression mechanisms, but clinical use remains investigational pending study completion and validation.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT06280820). This is a study registration, not published results. Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI). Recruitment status: ENROLLING_BY_INVITATION. Study type: OBSERVATIONAL. Enrollment: 2000 participants (ESTIMATED). Conditions: Heart Failure. Primary outcome measures: To study the association between multi-omics signatures with all-cause mortality , 10 years. Brief summary: Background: More than 6.5 million people in the United States live with heart failure (HF), and more than a million new cases are diagnosed each year. Treatments have improved in recent years, but researchers want to understand more about how HF develops. To do this, they need to compare blood and other samples from many people with HF. Objective: To collect blood and other samples from people with HF. These samples will be used to identify and study proteins and other factors that may lead to decreased heart function over time. Eligibility: People aged 18 years and older with heart failure. Design: Participants will be asked to join the study based on a review of their medical records. They will have 1 study visit. They will provide a blood sample: About 3 tablespoons will be collected from a needle inserted into a vein. Other tests are optional: Participants may provide urine and stool samples. They may have a cotton swab rubbed on the inside of the mouth to collect DNA. Participants may also take 3 questionnaires. They will answer questions about dietary, social, and other factors that affect their health. Participants will receive compensation. Researchers will follow the participants health by monitoring their medical records for up to 5 years.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.