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Life sciences · Observational Study
ClinicalTrials.gov · September 22, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT04926220). This is a study registration, not published results. Lead sponsor: Assistance Publique - Hôpitaux de Paris. Recruitment status: TERMINATED. Study type: OBSERVATIONAL. Enrollment: 36 participants (ACTUAL). Conditions: Interventional Radiology, Surgery, General Anesthesia, Organ Failure, Intensive Care, Hemodynamic Instability, Blood Pressure, Cardiac Output. Interventions: DEVICE: Trans-esophageal Doppler monitoring; DEVICE: MostCareUP Haemodynamic Monitor; DEVICE: Argos Cardiac Output (CO) Monitor. Primary outcome measures: Cardiac output using the trans-esophageal Doppler technique , Duration of the surgery (maximum 1 day); Cardiac output using the MostCareUp monitor , Duration of the surgery (maximum 1 day); Cardiac output using the Argos monitor , Duration of the surgery (maximum 1 day). Brief summary: During major surgery, it is recommended to monitor invasive arterial blood pressure and cardiac output (CO) during hemodynamic interventions (fluid challenge or vasopressors). Esophageal Doppler is currently considered as the reference method for monitoring cardiac output in the operating room. The PRAM method (pressure recording analytical method) with the MostCareUp monitor (Vytech, Padova, Italy) and the LTIA method (long time interval analysis) allow cardiac output estimation derived from non-calibrated arterial pressure waveform analysis. Few studies have looked at relative changes in cardiac output during hemodynamic intervention with these two methods. The aim of this study is to compare the relative changes in cardiac output during hemodynamic interventions as measured using PRAM and LTIA methods, compared to esophageal Doppler.