Fibromyalgia and Chronic Fatigue Syndrome Research / Obsessive Compulsive Spectrum Disorders / Psychosomatic Disorders and Their Treatments · Journal article
Allergy Medicine. · September 1, 2026
A consensus or society position rather than new primary data.
This narrative review proposes that allergic diseases (asthma, allergic rhinitis, atopic dermatitis) and psychiatric disorders (depression, anxiety, autism spectrum disorder) share common biological pathways involving chronic inflammation, immune dysregulation, and neuroimmune cross-talk. The authors recommend integrated diagnostic and therapeutic approaches informed by mechanistic understanding, supported by emerging technologies such as multi-omics and biosensors, rather than evidence from primary clinical trials.
Narrative review. Individuals with allergic diseases (asthma, allergic rhinitis, atopic dermatitis) and comorbid psychiatric disorders (depression, anxiety, autism spectrum disorder).
Allergic diseases frequently co-occur with depression, anxiety, and autism spectrum disorder Shared mechanisms include chronic inflammation, immune dysregulation, neuroimmune cross-talk, HPA axis dysfunction, and microbiota–gut–brain interactions Multi-omics profiling, nanotechnology, and wearable biosensors are proposed as tools for early detection and personalized treatment
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Clinicians managing allergic or psychiatric disorders should consider screening for comorbid conditions and recognize shared biological mechanisms; however, this review does not report evidence that specific interventions targeting these mechanisms improve outcomes.
A narrative review synthesizing epidemiological associations and mechanistic pathways between allergic and psychiatric disorders, proposing integrated diagnostic and therapeutic strategies rather than reporting original evidence.
As stated by the source record.
Clinicians managing allergic or psychiatric disorders should consider screening for comorbid conditions and recognize shared biological mechanisms; however, this review does not report evidence that specific interventions targeting these mechanisms improve outcomes.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no reported figures. That is a gap in the analysis, not a judgement about the study.
: Allergic diseases, including asthma, allergic rhinitis (AR), and atopic dermatitis (AD) frequently co-occur with psychiatric disorders such as depression, anxiety, and Autism spectrum disorder (ASD), reflecting their frequent co-occurrence and shared biological pathways. The etiology of these comorbidities is multifactorial, involving genetic, environmental, psychological, and immunological factors and their dynamic interactions. Both disease groups are characterized by chronic inflammation, immune dysregulation, and neuroimmune cross-talk, while epigenetic modifications, hypothalamic–pituitary–adrenal (HPA) axis dysfunction, and microbiota–gut–brain interactions have emerged as key mechanistic links. This convergence of immune and neural pathways suggests that allergic and psychiatric disorders may arise from common molecular and cellular processes rather than independent disease entities. Understanding these shared mechanisms may facilitate the development of integrated diagnostic and therapeutic strategies for allergic and psychiatric comorbidities. The rising global burden of allergy-psychiatry comorbidities underscores the urgent need for precision strategies that move beyond symptom management toward mechanistically informed interventions. Recent advances in multi-omics profiling, nanotechnology, and wearable biosensors offer unprecedented opportunities for early detection, real-time monitoring, and personalized treatment. In particular, nano-enabled biosensors capable of tracking neuroimmune biomarkers represent a transformative step in bridging immune, neurological, and mental health domains. By linking shared pathogenesis with technological innovation, this review highlights the critical importance of interdisciplinary research at the intersection of neuroimmunology, psychiatry, and biomedical engineering. Such approaches have the potential to redefine diagnostics and therapeutics for allergy-psychiatry comorbidities, improving clinical outcomes, reducing healthcare burden, and advancing patient-centered care.
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