Loading
Hypertension / Type 2 Diabetes · unknown
Journal of Diabetes and Metabolic Disorders · July 15, 2026
Reinforces what was already believed, rather than introducing something new.
This 10-year prospective cohort from the MASHAD study demonstrates that hematologic-inflammatory indices, particularly the neutrophil-to-lymphocyte ratio (NLR), are independently associated with all-cause mortality in individuals with type 2 diabetes. The associations varied by disease subgroup, with weaker findings in hypertension alone but persistent associations in those with both diabetes and hypertension.
Prospective cohort study. 1,170 diabetic and 2,022 hypertensive participants from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study. Intervention: Hematologic-inflammatory indices (SII, NLR, PLR, NLPR) as exposure variables.
Over 10 years, mortality rates were 11.3% in diabetic and 6.9% in hypertensive participants In diabetic individuals, adjusted HR for SII/100 was 1.15 (P = 0.001) and for NLR was 1.48 (P = 0.002) In hypertensive patients, NLR lost significance after adjustment (adjusted HR: 1.21, P = 0.080)
No data on cause-specific mortality or specific index cut-points for clinical use Over 10 years, mortality rates were 11.3% in diabetic and 6.9% in hypertensive participants
NLR appears to be a useful prognostic marker for all-cause mortality in diabetic patients and may aid in risk stratification, particularly in those with comorbid hypertension. The clinical utility in hypertension alone is limited given loss of significance after adjustment.
Prospective cohort analysis with 10-year follow-up demonstrates association between inflammatory markers and mortality in diabetes, with adjusted hazard ratios and consistent findings in subgroups.
As stated by the source record.
Quoted from the source exactly as published.
NLR appears to be a useful prognostic marker for all-cause mortality in diabetic patients and may aid in risk stratification, particularly in those with comorbid hypertension. The clinical utility in hypertension alone is limited given loss of significance after adjustment.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background. This study examines the relationship between hematologic-inflammatory indices and all-cause mortality in individuals with type 2 diabetes and hypertension.Methods. Using data from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study, 1,170 diabetic and 2,022 hypertensive participants were analyzed. The systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte-platelet ratio (NLPR) were calculated from complete blood counts and assessed using Cox regression models and Kaplan-Meier curves.Results. Over 10 years, mortality rates were 11.3% in diabetic and 6.9% in hypertensive participants. In diabetic individuals, SII/100 was associated with mortality in both unadjusted and adjusted models (HR: 1.10, P = 0.006; adjusted HR: 1.15, P = 0.001), while NLR was also significantly associated (HR: 1.38, P < 0.001; adjusted HR: 1.48, P = 0.002). PLR/100 was not significant in the unadjusted model (HR: 1.37, P = 0.174) but became significant after adjustment (HR: 1.86, P = 0.013). In hypertensive patients, NLR was significant only in the unadjusted model (HR: 1.26, P = 0.019) and lost significance after adjustment (adjusted HR: 1.21, P = 0.080). SII/100 was not significantly associated with mortality in either unadjusted or adjusted models (HR: 1.02, P = 0.603; adjusted HR: 1.05, P = 0.297). Among individuals with both diabetes and hypertension, NLR, PLR/100, and SII/100 remained significantly associated with mortality in adjusted models. Kaplan-Meier analysis showed consistent associations for NLR, whereas PLR, SII, and NLPR curves were mostly non-significant.Conclusion. Hematologic-inflammatory indices, particularly NLR, were associated with all-cause mortality mainly among individuals with diabetes and those with both diabetes and hypertension; however, the associations varied by index and disease subgroup.Clinical trial number. Not applicable.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.