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Life sciences · Journal article
Yakut Medical Journal · October 15, 2026
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Today, infectious diseases occupy a leading position among other diseases causing concerns among the population, leading to a decrease in work capacity and a number of serious complications. Monitoring infectious diseases and preparing for future outbreaks is crucial for the development of genetic epidemiology and public health in general. In this study, we analyzed the allele and genotype frequency distribution of the rs10774671 (G>A) variant of the OAS1 gene, previously associated with infectious diseases, in subpopulations of Bashkirs and Tatars living in the Volga-Ural region. We paid special attention to the study of subpopulations to obtain the most accurate results of the frequency distribution of this locus in such large populations as Bashkirs and Tatars. A study of the allele and genotype distribution of the rs10774671 genetic variant of the OAS1 gene was conducted using PCR followed by RFLP analysis. A pairwise comparison of allele frequencies between the studied populations revealed statistically significant differences between the Permsky Bashkirs subpopulation and the Askinsky, Burzyansky and Orenburgsky Bashkirs subpopulations (p<0.05). The Ewens-Watterson test for the total Bashkirs sample, including all the studied subpopulations, demonstrated the presence of balancing selection (Fo=0.5405, Fe=0.6461, p<0.05). A separate analysis of each subpopulation revealed the effect of balancing selection on the Orenburgsky Bashkirs (Fo=0.4375, Fe=0.5957, p<0.05). These results will add to our knowledge of the distribution of the rs10774671 genetic variant of the OAS1 gene in populations worldwide.