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Thyroid Gland / Breast Cancer Female / Chemotherapy · Observational Study
ClinicalTrials.gov · September 4, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a clinical trial registry record describing a planned observational study of thyroid dysfunction incidence in Chinese women with newly diagnosed breast cancer undergoing chemotherapy. No results have been posted; the study is actively recruiting. The protocol aims to fill a gap in understanding endocrine toxicity of chemotherapy, but the evidence base remains absent until data are reported.
Observational. Breast Cancer Female, Thyroid Gland; Female; age from 18 Years; to 85 Years. Intervention: Observational group; Control group. n = 400. 1 site: China.
This is a clinical trial registry record describing a planned observational study of thyroid dysfunction incidence in Chinese women with newly diagnosed breast cancer undergoing chemotherapy. No results have been posted; the study is actively recruiting. The protocol aims to fill a gap in understanding endocrine toxicity of chemotherapy, but the evidence base remains absent until data are reported.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is an active observational registry record with no reported results; it describes a planned study of thyroid toxicity during chemotherapy in breast cancer patients with estimated enrollment of 400.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT03177902). This is a study registration, not published results. Lead sponsor: The First Affiliated Hospital of Bengbu Medical University. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 400 participants (ESTIMATED). Conditions: Breast Cancer Female, Thyroid Gland. Interventions: DRUG: Chemotherapy. Primary outcome measures: Number of participants newly diagnosed with breast cancer , 1 week around the indicated detection point. Brief summary: Breast cancer is one of the most common cancers in China. Even though advances in the field of breast cancer therapeutics, chemotherapy remains the mainstay therapeutic modality. The cytotoxic therapies are generally associated with some immediate or otherwise delayed side effects, such as adverse effects on gastrointestinal, hepatic, renal and hematological systems. The effect of chemotherapy on endocrine system, however, is comparatively less envisaged. Several epidemiological studies show a positive association between plasma thyroid hormones levels and breast cancer risk. Thyroid dysfunction is emerging as a variably common endocrine toxicity of several anticancer drugs. Due to the scarcity of data on the functioning of thyroid gland during chemotherapy in a large scale group, the present study was aimed to investigate the incidence of thyroid abnormity in Chinese women with newly diagnosed breast cancer, and also the effects of chemotherapy on thyroid gland functions or structure in these breast cancer patients undergoing at least four cycles of chemotherapy.
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