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Life sciences · Interventional Study
ClinicalTrials.gov · September 15, 2026
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Interventional Study.
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Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
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Registry record from ClinicalTrials.gov (NCT07217223). This is a study registration, not published results. Lead sponsor: University of California, San Diego. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 10 participants (ESTIMATED). Conditions: Treatment Resistant Depression (TRD), Major Depressive Disorder (MDD). Interventions: DEVICE: Spaced Transcranial Direct Current Stimulation (tDCS). Primary outcome measures: Feasibility (Recruitment) , From baseline clinical assessment prior to treatment to 12 weeks after last treatment.; Feasibility (Retention) , From baseline clinical assessment prior to treatment, to 12 weeks after last treatment.; Feasibility (Adherence) , From baseline clinical assessment prior to treatment, to 12 weeks after last treatment.; Safety of at-home spaced tDCS , From baseline clinical assessment prior to treatment, to 12 weeks after last treatment.; Tolerability to spaced tDCS , From baseline clinical assessment prior to treatment, to 12 weeks after last treatment.. Brief summary: The investigators propose a single-arm, open-label study to evaluate the effectiveness, safety, tolerability and feasibility of at-home transcranial direct current stimulation (tDCS) as a treatment for depression, particularly in cases where patients have not responded well to traditional therapies. Treatment will be delivered over a 2-week period with daily weekday treatments i.e., five tDCS sessions, each lasting 20 minutes, spaced by approximately 20-minute inter-session intervals, for a total of three hours a day. Participants will self-administer treatment at home under direct remote supervision. Pre- and post- treatment neurophysiological biomarkers sessions will also be carried out. The study aims to examine changes in mood, brain activity, and related clinical outcomes before, during, and after treatment, with the goal to provide more information that can be used for future studies. PLEASE NOTE: THERE WILL BE 4 APPOINTMENTS THAT MUST OCCUR IN PERSON IN SAN DIEGO, CA.