Loading
Life sciences · Journal article
Obesities · October 26, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Background: Vitamin D insufficiency and deficiency are common in children and adolescents with chronic diseases and may coexist with lipid and glucose–insulin abnormalities. However, evidence across heterogeneous pediatric chronic conditions remains limited. This study aimed to compare these metabolic abnormalities according to vitamin D status in children and adolescents with chronic diseases. Methods: This retrospective cross-sectional study included 321 patients aged 6–17 years evaluated at a tertiary pediatric center in Mexico City, Mexico, with available serum 25-hydroxyvitamin D [25(OH)D], fasting glucose, lipid profile, and insulin measurements. Participants were classified as vitamin D-sufficient (25[OH]D ≥ 30 ng/mL) or -insufficient/deficient (<30 ng/mL). An exploratory multivariable logistic regression analysis was performed to evaluate factors associated with hypertriglyceridemia. Results: The median age was 13 years, 58.3% were female, and 65.8% had overweight or obesity. Vitamin D insufficiency/deficiency was present in 69.7% of participants. Hypertriglyceridemia was more frequent in patients with vitamin D insufficiency/deficiency than in those with sufficient vitamin D concentrations (37.5% vs. 21.6%; p = 0.005). Cholecalciferol supplementation differed markedly between groups, with all patients in the sufficient group receiving supplementation compared with 36.6% of those with insufficiency/deficiency. After adjustment for measured covariates, vitamin D insufficiency/deficiency remained associated with higher odds of hypertriglyceridemia (OR, 2.05; 95% CI, 1.02–4.09), while overweight/obesity showed a stronger association (OR, 2.70; 95% CI, 1.44–5.08). Conclusions: Vitamin D insufficiency/deficiency was common in this clinically selected cohort of children and adolescents with chronic diseases and remained associated with hypertriglyceridemia after adjustment for measured covariates. Overweight/obesity showed an even stronger association. These findings should be interpreted as exploratory and warrant confirmation in prospective studies.