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Life sciences · Interventional Study
ClinicalTrials.gov · November 3, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07786909). This is a study registration, not published results. Lead sponsor: Centre Leon Berard. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 40 participants (ESTIMATED). Conditions: Lung Neoplasms, Non Small Cell Lung Cancer. Interventions: BEHAVIORAL: Physical activity recommendations; BEHAVIORAL: Physical Activity (PA) Intervention. Primary outcome measures: Evaluate the effect of a structured exercise program on immune pathological response (irPR) , T2 (pre-surgery):. Brief summary: Recent advances combining chemotherapy and immunotherapy before surgery have significantly improved outcomes for patients with resectable non-small cell lung cancer (NSCLC). However, a substantial proportion of patients still do not respond optimally to these treatments. Researchers believe that physical activity may help strengthen the immune system and favorably modify the tumor microenvironment, potentially improving treatment effectiveness. ERICA-02 aims to investigate this hypothesis.The primary objective of ERICA-02 is to evaluate whether a structured exercise program performed during neoadjuvant chemo-immunotherapy can increase the presence of CD8+ cytotoxic T lymphocytes within the tumor. These immune cells play a key role in recognizing and destroying cancer cells and are considered an important marker of anti-tumor immune response.The study is designed for adults with locally advanced, resectable non-small cell lung cancer who are eligible for neoadjuvant chemo-immunotherapy followed by surgery. Participants must be medically fit to engage in physical activity, able to comply with study procedures, and provide informed consent before enrollment.ERICA-02 is a multicenter, randomized phase II pilot trial involving approximately 40 patients. Participants will be randomly assigned to one of two groups : intervention group and control group. Each participant will be involved in the study for approximately six months, including three months of exercise intervention for patients assigned to the exercise group.