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Late Life Depression (LLD) · Observational Study
ClinicalTrials.gov · August 17, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registry record for an ongoing observational follow-up study of late-life depression in adults aged ≥60, designed to track mortality and dementia incidence over 6–12 years and evaluate predictive value of neuroimaging and blood biomarkers. No results are yet posted in this registry; the study remains in enrollment and outcome data are not available for clinical decision-making.
Observational. Late Life Depression (LLD); age from 65 Years; accepts healthy volunteers. Intervention: Late-life depression group; Healthy controls. Compared with: Age and sex-matched healthy controls. n = 178. 1 site: Belgium.
This is a registry record for an ongoing observational follow-up study of late-life depression in adults aged ≥60, designed to track mortality and dementia incidence over 6–12 years and evaluate predictive value of neuroimaging and blood biomarkers. No results are yet posted in this registry; the study remains in enrollment and outcome data are not available for clinical decision-making.
This registry record contains no outcome results; study is currently enrolling and no efficacy or safety data are yet available.
The source did not state who this applies to in practice.
This is a registry record for an ongoing observational follow-up study with no results yet reported; it describes planned enrollment and outcome measures but carries no outcome data.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07768098). This is a study registration, not published results. Lead sponsor: Universitaire Ziekenhuizen KU Leuven. Recruitment status: ENROLLING_BY_INVITATION. Study type: OBSERVATIONAL. Enrollment: 178 participants (ESTIMATED). Conditions: Late Life Depression (LLD). Primary outcome measures: Number of Participants Who Died , From enrollment in the initial cross-sectional study until date of death from any cause, assessed up to 12 years for cohort 1 and up to 6 years for cohort 2.; Number of Participants with Dementia , From enrollment in the initial cross-sectional study to the follow-up assessment, an average of 12 years for cohort 1 and 6 years for cohort 2. Brief summary: The goal of this observational study is to learn about the long-term effects of late-life depression (LLD) in adults aged 60 and older. LLD is depression that begins for the first time later in life. Patients with this condition may feel sad for a long time or lose interest in activities they used to enjoy. They may also have problems with sleep, energy, or concentration. In some patients, this depression comes with changes in thinking and memory, which may be linked to a higher risk of dementia. The investigators believe that changes in the brain play a role in this condition. The main questions this study aims to answer are: Do patients with late-life depression have a higher risk of memory decline, dementia, return of depression, hospital stays, or death compared to healthy people? Can brain scans and blood tests help predict how the illness will develop over time? The investigators will compare patients with late-life depression to healthy people of the same age and sex. This will help clarify how the illness develops over several years. This is a follow-up study, which means no new treatment is being tested. The investigators will recruit participants from previous studies, drawn from two cohorts with a mean follow-up time since inclusion of 12 years and 6 years. The investigators collect information about health, memory, and mood, and compare it with earlier measurements. To do this, the investigators use existing information from past studies, medical records, brain scans, and blood samples. Participants can take part if they: Are at least 60 years old Took part in one of the earlier studies Give written permission to join Participants may be asked to: Have a conversation and take memory tests Give a blood sample Have a brain scan These tests can take place in the hospital or at the participant's home. If a participant does not want to do the tests again, the investigators can ask their family doctor for important health information, with the participant's permission.
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