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Life sciences · Observational Study
ClinicalTrials.gov · October 16, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT05303896). This is a study registration, not published results. Lead sponsor: Oslo University Hospital. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 200 participants (ESTIMATED). Conditions: Heart Failure. Primary outcome measures: MRI functional parameters including Left Ventricular Ejection Fraction and Global Longitudinal Strain , 1 years; MRI morphological parameters including LVEDV and LVESV. , 1 years; Myocardial stiffness measured by MRI and ex-vivo methods. , 1 year. Brief summary: Despite improvements in therapy, heart failure is a disease with high mortality and accelerating prevalence. To improve patient care, it is necessary to better understand the features and underlying mechanisms of myocardial remodeling; how it manifests in vivo and its underlying cellular and extracellular changes. The RELAX study will offer insight into myocardial remodeling, by comprehensively assessing function and structure of failing human hearts, and investigate its underlying cellular and extracellular changes.