New England Journal of Medicine · Randomized Controlled Trial · 2026-07-24
Potentially Practice-ChangingSeven versus fourteen days of antibiotics for Gram-negative bacteremia: a multicenter noninferiority trial
Why it matters. Supports shorter-duration stewardship targets and could reduce selection pressure driving resistance in your facilities.
Study design
- Design
- Multicenter, open-label, noninferiority RCT
- Population
- Hospitalized adults with Gram-negative bacteremia
- Setting
- 12 centers, 3 countries
- Sample size
- n = 604
- Intervention
- 7 days of active antibiotics
- Comparator
- 14 days of active antibiotics
Provenance
- Source
- New England Journal of Medicine
- Source type
- peer_reviewed
- Content analyzed
- abstract
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Discussion
clinical relevance · on outcome
Note the exclusion of immunocompromised hosts, I would not generalize the 7-day target to neutropenic patients yet.
Written by human
Strong design, but note the exclusion of immunocompromised hosts. I would not generalize the 7-day target to neutropenic patients yet.
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