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Aging and Exercise Impacts on Glymphatic Function / Acute Aerobic exercise · Interventional Study
ClinicalTrials.gov · August 20, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned, single-center, uncontrolled interventional study registered but not yet recruiting. It aims to measure acute aerobic exercise effects on cerebrospinal fluid dynamics and glymphatic function using MRI in cognitively normal adults across two age strata. No results are reported in this registry record.
Interventional, Single Group, Open label, Basic Science purpose. Aging and Exercise Impacts on Glymphatic Function; age from 25 Years; to 75 Years; accepts healthy volunteers. Intervention: Acute aerobic exercise- Interventional Group. n = 240. Single center: University of Texas Southwestern Medical Center (location not specified beyond institution name).
This is a planned, single-center, uncontrolled interventional study registered but not yet recruiting. It aims to measure acute aerobic exercise effects on cerebrospinal fluid dynamics and glymphatic function using MRI in cognitively normal adults across two age strata. No results are reported in this registry record.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is an uncontrolled, non-randomized, single-center registry record with no results posted; it describes a planned observational intervention study without a comparator arm.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07775196). This is a study registration, not published results. Lead sponsor: University of Texas Southwestern Medical Center. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 240 participants (ESTIMATED). Conditions: Aging and Exercise Impacts on Glymphatic Function. Interventions: PROCEDURE: Acute Aerobic exercise. Primary outcome measures: Exercise-induced changes in heart rate (HR) , Baseline (pre-exercise), immediately post-exercise; Exercise-induced changes in cardiac output (CO) , Baseline (pre-exercise), immediately post-exercise; Exercise-induced changes in MRI measurements of pCSF dynamics , Baseline (pre-exercise), immediately post-exercise; Exercise-induced changes in MRI measurements of CSF-ISF exchange , Baseline (pre-exercise), immediately post-exercise. Brief summary: This is a prospective, interventional, non-blinded, single center research project that will recruit cognitively unimpaired subjects in the 25-55 year old and 55-75 year old range. This study will use acute aerobic exercise as a natural intervention model to increase cardiac activity which may further drive the glymphatic function. There will be no randomization, and all enrolled subjects will participate in the exercise session. Hypotheses: revealed by the multi-modal magnetic resonance imaging (MRI) approach, glymphatic dysfunction increases with age and is associated with preclinical Alzheimer's Disease (AD) pathology in cognitively unimpaired individuals. Using acute aerobic exercise as a human model, the enhancement of cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange caused by elevated cardiac activity and paravascular cerebrospinal fluid (pCSF) dynamics can be validated.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.