Life sciences · Observational Study
ClinicalTrials.gov · October 6, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT06790160). This is a study registration, not published results. Lead sponsor: Texas Tech University. Recruitment status: ACTIVE_NOT_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 100 participants (ACTUAL). Conditions: Obesity and Overweight. Primary outcome measures: Change in Total Lean Soft Tissue , From baseline assessment to last available time point (follow-up assessments conducted ~6 months and ~17 months after baseline).; Change in Appendicular Lean Soft Tissue , From baseline assessment to last available time point (follow-up assessments conducted ~6 months and ~17 months after baseline).; Change in Total Fat Mass , From baseline assessment to last available time point (follow-up assessments conducted ~6 months and ~17 months after baseline).; Change in Handgrip Strength , From baseline assessment to last available time point (follow-up assessments conducted ~3, ~6, and ~17 months after baseline).. Brief summary: The goal of this observational study is to learn about the real-world effects of selected obesity medications in adults undergoing medical weight management. The main outcomes of interest are changes in body composition, routine clinical markers, muscular performance, and nutritional intake over the course of treatment. Additionally, the influence of lifestyle factors on changes in these outcome variables will be examined. Participants beginning treatment with selected obesity medications will undergo periodic body composition and muscular performance testing, as well as complete online surveys about their nutritional intake and physical activity and exercise participation. Additionally, routinely collected clinical information will be evaluated.