Life sciences · Observational Study
ClinicalTrials.gov · October 27, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT04748276). This is a study registration, not published results. Lead sponsor: Adams Clinical. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 400 participants (ESTIMATED). Conditions: Major Depressive Disorder. Interventions: DRUG: FDA-approved selective-serotonin reuptake inhibitors (SSRIs) and selective-norepinephrine reuptake inhibitors (SNRIs). Primary outcome measures: Change in Hamilton Depression Inventory - 17 item (HAM-D) total score in response to a treatment cycle from Baseline/Day 0 to the end of a 6-week treatment cycle. , Up to 33 weeks. Brief summary: TRAIT is an open-label observational study to evaluate treatment response to selective-serotonin reuptake inhibitors (SSRIs) and selective-norepinephrine reuptake inhibitors (SNRIs) among individuals meeting criteria for Major Depressive Disorder (MDD) and seeking enrollment in investigational trials.