Loading
Life sciences · Journal article
Clinical and Translational Discovery · September 18, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Abstract Background Bioactive peptides (BAPs), derived from both natural and synthetic sources, are increasingly recognized as multifunctional agents with potential roles in the management of cancer and inflammatory conditions, in addition to their well‐established antimicrobial activity. Their biological activity is critically governed by their sequence‐dependent physicochemical properties, including charge hydrophobicity, amphipathicity, and well‐defined three‐dimensional conformation, such as α‐helices, β‐sheets, and coils, which collectively determine target specificity, membrane interaction, and intracellular activity, ultimately determining therapeutic effectiveness and safety. Method Aside from in vitro models, animal models further validated their efficacy, enabling mechanistic insights and high‐throughput screening. Result In cancer models, BAPs induce anti‐cancer activity through various mechanisms such as membrane disruption, mitochondrial dysfunction, ROS generation, apoptosis, inhibition of invasion, migration, and angiogenesis across multiple cancer types, including breast cancer, particularly triple‐negative breast cancer, colorectal, lung and melanoma, highlighting BAPs broad antitumor properties. Concurrently, BAPs regulate the immune system through cytokine modulation, NF‐κB signalling suppression, reduced immune cell infiltration and macrophage polarization promotion. Conclusion However, despite these advances, clinical translation remains limited due to poor stability, short half‐life, cytotoxicity, high production costs and optimized drug delivery systems. An integrated multidisciplinary approach with AI‐guided design places BAPs as promising precision medicine tools for specific, immunomodulatory, and personalized anticancer and anti‐inflammatory therapies.