Loading
Life sciences · Preprint
arXiv · November 5, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Preprint.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
State-space models (SSMs) recover low-dimensional latent dynamics from high-dimensional observations, but latents are generally not identifiable from observational data alone. Interventional state-space models (iSSMs) use perturbations to break observational symmetries and identify parameters up to permutation, scaling, and shift. However, prior work restricts identifiability to linear latent dynamics and piecewise-linear emissions, excluding many behaviors characteristic of neural circuits. We extend iSSMs to a substantially broader model class: we prove that (i) affine identifiability holds under general injective emission functions and Gaussian latent transitions, and (ii) with interventions, identifiability up to permutation, scaling, and shift is preserved under general nonlinear latent dynamics. We validate our theory on simulated FitzHugh-Nagumo dynamics, and then demonstrate two applications: adjudicating between competing models of decision-making; and predicting responses to unseen micro-stimulation in macaque and human neural recordings, with proof-of-concept generalization to a held-out stimulation site in the latter. Finally, simulations yield practical guidance for designing stimulation protocols that improve identifiability.