Life sciences · Phase 4 Trial
ClinicalTrials.gov · September 24, 2026
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Phase 4 Trial.
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Registry record from ClinicalTrials.gov (NCT06746753). This is a study registration, not published results. Lead sponsor: Wake Forest University Health Sciences. Recruitment status: NOT_YET_RECRUITING. Phase: PHASE4. Study type: INTERVENTIONAL. Enrollment: 78 participants (ESTIMATED). Conditions: Septic Shock. Interventions: DRUG: Angiotensin II; DRUG: Norepinephrine. Primary outcome measures: Mean Renin Level - Hour 24 , Hour 24. Brief summary: Despite best therapy efforts, sepsis and septic shock are associated with mortality rates of up to 40%. This clinical trial will determine the benefit of exogenous Angiotensin II versus norepinephrine (conventional care) treatment in septic shock patients. This trial will determine whether there are better predictors of septic shock severity. This approach may inform more appropriate treatment regimens and improve outcomes for these patients.