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Life sciences · Observational Study
ClinicalTrials.gov · October 8, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07718841). This is a study registration, not published results. Lead sponsor: Spanish Breast Cancer Research Group. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 300 participants (ESTIMATED). Conditions: Early Breast Cancer (EBC). Interventions: OTHER: biological samples, images, and clinical data. Primary outcome measures: Prognostic and Predictive Value of ctDNA in Patients Receiving NAT , From Study Start Date to Primary Completion Date (25 months).. Brief summary: The goal of this observational study is to explore the utility of analytical techniques that enable the study of small amounts of tumor-derived material circulating in the blood, such as fragments of circulating tumor DNA (also known as ctDNA), cells, or other particles. This type of sample is generally referred to as a liquid biopsy, and its analysis is a minimally invasive test, as it only requires the collection of blood samples. The study includes women and men with early-stage breast cancer (EBC) who are about to start neoadjuvant treatment (treatment given before surgery). The main questions it aims to answer are: * Can liquid biopsy analyses (ctDNA) provide additional information about the type of tumor before treatment starts? * Can these analyses help to detect early whether the tumor is responding to treatment? * Can these tests identify if any cancer remains after neoadjuvant treatment or after surgery? * Is this information related to the risk of the cancer coming back? * Can these analyses, when performed during follow-up, help detect cancer recurrence earlier? Participants will: * Continue receiving standard medical care for their breast cancer, including neoadjuvant therapy and surgery. * Provide blood samples at different time points during treatment and follow-up. * Provide residual tumor samples from the routine clinical care.