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Life sciences · Preprint
arXiv · October 7, 2026
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Continual learning requires models to adapt to new domains and new classes while retaining prior knowledge. Many existing methods rely on continued optimization, using regularization, replay, or parameter expansion to prevent new updates from overwriting previously learned knowledge. Instead, we propose replacing continual training with continual inference: a PFN-based model that is meta-trained, and then frozen, adapting to new classes only by extending an in-context evidence set. Our model, Latent Concept PFN, performs in-context Bayesian inference over a latent concept space that captures semantic structure shared across domains and classes. As each new domain or class arrives, exemplars are added to the memory; adaptation reflects updated posterior beliefs over latent concepts rather than gradient updates. No parameters are changed, reducing forgetting. The same method handles both domain and class incremental continual learning without task identity. Concept annotations are only used during meta-training, acting as a soft anchor on the latent space rather than a fixed bottleneck. Unlike fixed-vocabulary concept methods, the model also handles noisy, ambiguous, or incomplete annotations by combining concept labels with raw input evidence to discover distinctions beyond the predefined concept set. Experiments on class and domain incremental learning datasets demonstrate competitive continual learning performance while learning interpretable latent concepts.