Life sciences · Preprint
arXiv · September 22, 2026
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Causal tabular foundation models amortize effect estimation across synthetic mechanisms, but latent-effect supervision rewards posterior shrinkage instead of directly encoding the repeated-sample response needed in a fixed deployment population. We introduce fluctuation-supervised pretraining (FSP): each synthetic table is labeled by its average treatment effect plus its efficient influence-function fluctuation, while deployment remains a single frozen forward pass. Along the path $T_{λ,P}=θ(P)+λP_nψ_P$, we prove an endpoint transition: every fixed $λ<1$ retains label ambiguity of order $(1-λ)^2/n$, whereas full fluctuation makes the Gaussian label observable and reduces optimal finite-stratum causal label-prediction risk to order $n^{-2}$. One finite-pretraining bound combines label, network, episode-sampling, and optimization errors; its resulting sampling defect controls fixed-mechanism bias, mean squared error, variance, Gaussian approximation, and, with variance-head accuracy, studentized coverage. Complementary lower bounds separate the local $n^{-1}$ ATE risk that deployment observations cannot erase from the $\log N/M$ excess risk of a generic finite-dictionary episode-learning problem. Experiments trace the learned sampling response. With a raw-row/column backbone, FSP reduces large-effect-shift RMSE by 69.8% relative to latent supervision and by 39.5% relative to a released CausalPFN checkpoint on matched tables. Continuous-covariate experiments, known-effect semisynthesis and two randomized-study evaluations separate sampling-law fidelity from point-risk shrinkage and expose weak-overlap errors in both learned heads.