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Life sciences · Interventional Study
ClinicalTrials.gov · September 28, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Interventional Study.
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Registry record from ClinicalTrials.gov (NCT04225507). This is a study registration, not published results. Lead sponsor: University of Chicago. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 182 participants (ACTUAL). Conditions: Sleep Apnea, PreDiabetes, Overweight or Obesity. Interventions: BEHAVIORAL: Diet and exercise coaching; OTHER: CPAP Treatment. Primary outcome measures: Change from baseline 2-hour glucose levels at 6 months , Baseline and at 6 months. Brief summary: Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular complications in this high-risk population. Sleep apnea is a highly common condition in prediabetes, but it has been mostly ignored and undertreated in current practice. The proposed study will be the first to assess whether adding CPAP (continuous positive air pressure) treatment to a lifestyle intervention improves cardiometabolic outcomes beyond that achieved with lifestyle alone (i.e. current standard of care) in high-risk individuals with prediabetes.