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Nonlinear Aerobic Training / Cardiopulmonary exercise test / Height, Weight, BMI measure · Interventional Study
ClinicalTrials.gov · August 5, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned interventional study registered at ClinicalTrials.gov examining the dose-response relationship between progressive aerobic training and gene expression patterns in breast epithelial tissue among women at high risk for breast cancer. The registry record contains no reported results and is currently active but not recruiting.
Interventional, Randomized, Parallel, Open label, Prevention purpose. High Risk for Developing Breast Cancer; Female; age from 18 Years. Intervention: Nonlinear Aerobic Training (75 minutes/week) closed to accr…; Nonlinear Aerobic Training (150 minutes/week); Nonlinear Aerobic Training (300 minutes/week). Compared with: General Physical Activity — Active Comparator. n = 75. 1 site: United States.
This is a planned interventional study registered at ClinicalTrials.gov examining the dose-response relationship between progressive aerobic training and gene expression patterns in breast epithelial tissue among women at high risk for breast cancer. The registry record contains no reported results and is currently active but not recruiting.
Registry record only; no results reported or data on efficacy, safety, or outcome measures
Once results are published, this study may inform the optimal dose of aerobic exercise for modifying gene expression and inflammatory biomarkers associated with breast cancer risk. Clinicians should await peer-reviewed publication before integrating findings into practice.
This is an active clinical trial registry record with no posted results; it describes a planned intervention study in a high-risk population with gene expression as primary outcome.
As stated by the source record.
Quoted from the source exactly as published.
Once results are published, this study may inform the optimal dose of aerobic exercise for modifying gene expression and inflammatory biomarkers associated with breast cancer risk. Clinicians should await peer-reviewed publication before integrating findings into practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT02494869). This is a study registration, not published results. Lead sponsor: Memorial Sloan Kettering Cancer Center. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 75 participants (ACTUAL). Conditions: High Risk for Developing Breast Cancer. Interventions: BEHAVIORAL: Nonlinear Aerobic Training; OTHER: Height, Weight, BMI measure; OTHER: Blood draw; OTHER: Cardiopulmonary exercise test. Primary outcome measures: gene expression patterns of non-neoplastic breast epithelial cells in women at high-risk for development of breast cancer , 2 years. Brief summary: This study is being done to look at the effect that different amounts of progressive exercise training has on risk factors associated with developing breast cancer. These risk factors include exercise capacity, body weight, and body composition, as well as the expression of certain genes and levels of inflammatory factors in your breast tissue. The participant will be instructed to self-report the session information to ExOnc staff at or before their next scheduled visit. If the participant's next scheduled visit is greater than 72 hours following an unsupervised session, ExOnc staff may reach out to the participant to retrieve the session information. Unsupervised session details will be source documented by ExOnc staff.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.