Life sciences · Preprint
arXiv · September 16, 2026
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Quantum Reinforcement Learning (QRL) represents policies as variational quantum circuits (VQCs), making it attractive for combinatorial optimization such as the Capacitated Vehicle Routing Problem (CVRP). On noisy intermediate-scale quantum (NISQ) hardware, however, decoherence degrades fidelity and destabilizes learning, and conventional error mitigation is applied statically without regard to the learning context. We introduce Adaptive Policy-Guided Error Mitigation (APGEM), a controller that selects among Zero-Noise Extrapolation (ZNE), Probabilistic Error Cancellation (PEC), Clifford Data Regression (CDR), and Readout Error Mitigation (REM) online, driven by a fidelity, entropy, and cost aware utility function and an epsilon-greedy rule over temporal-difference Q-scores. We evaluate on a realistic urban-logistics testbed, a Delhi-based CVRP over real landmarks with geodesic inter-node costs, exercised across five noise families and four severity levels. On this instance, the QRL agent outperforms constructive heuristics and approaches metaheuristics, while mitigation restores approximation ratios from 0.84-0.87 to 0.92-0.94 under high noise. The controller shifts from a CDR-dominated regime under short training horizons to a balanced deployment across all four techniques under longer horizons, indicating genuine regime-dependent selection. These preliminary results position adaptive, learning-aware mitigation as a practical route to noise-resilient QRL.