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Life sciences · Observational Study
ClinicalTrials.gov · November 4, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07917117). This is a study registration, not published results. Lead sponsor: Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 50 participants (ESTIMATED). Conditions: Quality of Life, Breast Neoplasms, Skin Aging, Hyaluronic Acid. Interventions: OTHER: Intradermal injection. Primary outcome measures: Change in Skin Hydration and Elasticity From Baseline , Before the treatment and at 4 and 24 weeks after the initial treatment. Brief summary: Systemic treatments such as chemotherapy or monoclonal antibodies are an essential part of oncological treatment in breast cancer, which have demonstrated a survival benefit (1,2,3,4,5). This cancer is the most common cancer in women, being the cancer with the highest incidence worldwide (6), with an estimated 35,001 new cases in 2023 in Spain (7). This is why a large number of patients receive systemic treatments that help surgery and radiotherapy to achieve a cure of over 80% in our environment, with a 5-year overall survival of 85.5% having been described (7). These systemic oncological treatments generate well-known skin alterations such as xerosis, pruritus, erythema, pigmentation alterations, papulo-pustular eruptions, dermatosis, and others such as psoriasis (8,9,10,11). The multimodal treatment of cancer finally becomes a long and hard process which, added to the fear of the diagnosis itself, and the physical changes as a consequence of these treatments, end up reducing the state of mind of the patients who suffer from it (12,13,14). Self-care and the aesthetic improvement of the patient's appearance are the main reasons for this. There are aesthetic treatments, such as hyaluronic acid 12mg/ml cross-linked (VYC-12L) in intradermal injection, that could improve the quality and aesthetics of the facial skin, which could help to improve the self-perception of patients who receive it, helping them to recover their self-confidence and improve their quality of life. Research Question: To objectively compare the skin quality of patients with previous history of breast cancer who have received and completed treatment with chemotherapy and/or monoclonal antibodies, before and after intradermal injection a cross-linked hyaluronic acid 12mg/ml (VYC-12L) in addition to self-esteem and quality of life.