Breast Cancer Survivors / Aerobic Exercise · Interventional Study

Assessing the Effect of an Aerobic Exercise Program on Vascular Function in Women With Non-Metastatic Breast Cancer

ClinicalTrials.gov · August 4, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a registered feasibility and pilot study protocol for an 8-week aerobic exercise intervention in breast cancer survivors, designed to assess recruitment, adherence, retention, and vascular function markers. No results have been posted in this registry record; the study is in the planning phase and has not yet begun enrollment.

What was studied

Interventional, Single Group, Open label, Supportive Care purpose. Breast Cancer Survivors; Female; age from 18 Years; to 70 Years. Intervention: Exercise Intervention. n = 40. Loyola University (specific centres and country not detailed).

Key findings

Safety

Registry record contains no results, outcome data, or safety findings; study has not yet begun recruitment

Who this may help

This protocol describes a planned feasibility study only; clinicians should recognize that no evidence regarding efficacy or safety is available at this stage. Results are needed to inform whether this exercise intervention warrants further investigation in larger trials.

Plain-language summary

This is a feasibility study registration with no results reported; enrollment is planned but not yet recruiting, making it a preliminary stage protocol for assessing exercise intervention feasibility and vascular outcomes in breast cancer survivors.

Study design

As stated by the source record.

MethodsPrimary outcome measures: Enrollment (Recruitment rate) (assessed at From enrollment to immediately after first visit); Participant adherence - Proportion of people considered adherent (assessed at From enrollment to the end of intervention at 8 weeks); Retention - Proportion of survivors who completed the study (assessed at From enrollment to the end of intervention at 8 weeks); Pulse Wave Velocity (assessed at From enrollment to the end of intervention at 8 weeks"); Aortic Blood Pressure (assessed at From enrollment to the end of intervention at 8 weeks)

DesignInterventional, Single Group, Open label, Supportive Care purpose

PopulationBreast Cancer Survivors; Female; age from 18 Years; to 70 Years

Sample size40

InterventionExercise Intervention

SettingLoyola University (specific centres and country not detailed)

Reported figures

Quoted from the source exactly as published.

Planned enrollment40

Intervention duration8 weeks

Exercise frequency3 days per week

Primary outcome: Enrollment (recruitment rate)From enrollment to immediately after first visit

Primary outcome: Pulse Wave VelocityFrom enrollment to end of intervention at 8 weeks

Primary outcome: Aortic Blood PressureFrom enrollment to end of intervention at 8 weeks

Clinical bottom line

Caveats

Registry record contains no results, outcome data, or safety findings; study has not yet begun recruitment
Feasibility study with no control or comparator arm; cannot assess efficacy relative to standard care or attention control
Study is estimated at 40 participants, appropriate only for feasibility assessment, not for definitive efficacy claims
Enrollment status is NOT_YET_RECRUITING; timeline to completion and data availability unknown

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

moderate

Interventional feasibility study design stated; no comparator arm mentioned

Directness

strong

Directly addresses vascular function outcomes in breast cancer survivors post-chemotherapy

Consistency

insufficient

Single study registration; no comparative efficacy data available

Risk of bias

insufficient

No results reported; study not yet recruiting; no blinding or control design described

Sample adequacy

limited

Estimated 40 participants planned; appropriate for feasibility assessment only

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT07517224). This is a study registration, not published results. Lead sponsor: Loyola University. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 40 participants (ESTIMATED). Conditions: Breast Cancer Survivors. Interventions: OTHER: Aerobic Exercise. Primary outcome measures: Enrollment (Recruitment rate) , From enrollment to immediately after first visit; Participant adherence - Proportion of people considered adherent , From enrollment to the end of intervention at 8 weeks; Retention - Proportion of survivors who completed the study , From enrollment to the end of intervention at 8 weeks; Pulse Wave Velocity , From enrollment to the end of intervention at 8 weeks"; Aortic Blood Pressure , From enrollment to the end of intervention at 8 weeks. Brief summary: The goal of this clinical trial is to assess the feasibility of an 8-week aerobic exercise program and its effect on arterial function in breast cancer survivors. The main questions it aims to answer are: * Is an 8-week aerobic exercise program feasible in breast cancer survivors after the completion of chemotherapy? * Is this 8-week aerobic exercise program beneficial for vascular function in breast cancer survivors? Participants will: * Begin an 8-week aerobic exercise program, three days per week, after the completion of chemotherapy. * Visit our facility three times before the exercise program, 1 month after, and after the completion of the program. * Complete questionnaires, physical functional tests, and body composition and vascular measurements at every visit.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

NCT07517224Breast Cancer SurvivorsAerobic ExerciseLoyola University