Life sciences · Preprint
arXiv · November 6, 2026
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In many domains from species identification to cancer diagnosis, labelling data to train predictive models remains costly. In these settings, it is advantageous to intelligently select data points to label to achieve the maximum information gain, this is the motivation behind the study of active learning. In addition to the high costs of acquiring data in such domains, there is the added complexity of data distribution shifts that can occur between training and deployment. For example, the features of cancerous skin cells taken in one country may be different in another region of the world. These two challenges - efficient labelling of data, and learning models robust to distribution shifts have been studied separately but not together, even though these challenges often co-occur in real-life settings. We identify failure modes of standard active learning approaches when the distribution of data at deployment is different from the distribution in which the data is sampled for labelling. We propose a new strategy for efficiently learning classifiers that generalise under specific forms of distribution shift, namely subpopulation shift. Drawing on work in learning from heterogeneous data, we aim to train models that perform well across subpopulations of the data, through active learning. To handle this challenging setting, we exploit the fact that many datasets include metadata about data collection that can serve as a noisy proxy for each sample's underlying subpopulation. We demonstrate how to leverage these noisy labels during active learning selection, and demonstrate empirically that our approach improves classifier accuracy across subpopulations.