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Obesity, Morbid / High flow nasal cannula / Noninvasive ventilation alternating with high flow nasal cannula · Interventional Study
ClinicalTrials.gov · August 7, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a recruiting interventional trial comparing noninvasive ventilation alternating with high-flow nasal cannula to high-flow nasal cannula alone in severely obese patients after planned extubation. No efficacy or safety results have been posted in this registry record; the study is designed to evaluate whether prophylactic noninvasive support reduces treatment failure (defined by need for rescue respiratory support within 72 hours) in a population at elevated risk of extubation failure.
Interventional, Randomized, Parallel, Open label, Prevention purpose. Obesity, Morbid, Extubation Failure; age from 18 Years. Intervention: Intervention Group (NIV with HFNC). Compared with: Control Group (HFNC alone) — Active Comparator. n = 250. 5 sites: United States, Mexico.
Primary outcome: treatment failure defined by use of rescue respiratory support for acute respiratory failure in the first 72 hours after planned extubation Background: approximately 20% of obese patients with higher BMI require reintubation after extubation
This registry record reports no results; efficacy and safety data are not yet available
The source did not state who this applies to in practice.
This is a recruiting interventional trial with no posted results; the registry record describes the planned design and primary outcome measure only, precluding assessment of efficacy or harm.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Registry record from ClinicalTrials.gov (NCT05918575). This is a study registration, not published results. Lead sponsor: Rush University Medical Center. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 250 participants (ESTIMATED). Conditions: Obesity, Morbid, Extubation Failure. Interventions: DEVICE: Noninvasive ventilation alternating with high flow nasal cannula; DEVICE: High flow nasal cannula. Primary outcome measures: Treatment failure defined by use of rescue respiratory support for acute respiratory failure in the first 72 hours after planned extubation , 72 hours. Brief summary: Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.