Life sciences · Interventional Study
ClinicalTrials.gov · October 2, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT05326750). This is a study registration, not published results. Lead sponsor: Kuopio University Hospital. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 200 participants (ESTIMATED). Conditions: Alzheimer Disease, Frontotemporal Dementia, Dementia With Lewy Bodies. Interventions: DEVICE: Gamma tACS (40 Hz) over the superior parietal cortex. Primary outcome measures: Changes in Rey Auditory Verbal Learning Test score , Baseline (immediately before the intervention), immediately after the first intervention, immediately after the 4th intervention, 4 weeks after the last intervention; Changes in Rey Auditory Verbal Learning Test, recognition , Baseline (immediately before the intervention), immediately after the first intervention, immediately after the 4th intervention, 4 weeks after the last intervention; Changes in orientation to time and place (MMSE questions 1-10) , Baseline (immediately before the intervention), immediately after the last intervention, 4 weeks after the last intervention; Changes in Trail Making A & B tests , Baseline (immediately before the intervention), immediately after the 4th intervention, 4 weeks after the last intervention; Changes in INECO Frontal Screening test , Baseline (immediately before the intervention), immediately after the 4th intervention, 4 weeks after the last intervention; Changes in phonemic fluency , Baseline (immediately before the intervention), immediately after the first intervention, immediately after the 4th intervention, 4 weeks after the last intervention. Brief summary: Double blinded, sham-controlled, randomized trial on repeated transcranial alternating current brain stimulation (tACS) in neurodegenerative diseases. The investigators will evaluate whether a 4-times daily repeated stimulation with gamma tACS on the posterior parietal cortex can improve symptoms in patients with neurodegenerative diseases, including dementia with Lewy Bodies, Alzheimer's disease, idiopathic normal pressure hydrocephalus and Frontotemporal dementia.