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Life sciences · Observational Study
ClinicalTrials.gov · November 2, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07399288). This is a study registration, not published results. Lead sponsor: China Medical University Hospital. Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 73404 participants (ACTUAL). Conditions: Herpes Zoster, Dementia, Postherpetic Neuralgia (PHN). Interventions: OTHER: Exposure: postherpetic neuralgia. Primary outcome measures: Incident all-cause dementia , From the 365-day landmark after the index herpes zoster date to the earliest of the first record of dementia, death or the last recorded fact, up to the date of data extraction.. Brief summary: This retrospective observational cohort study uses de-identified electronic health record data from the TriNetX Global Collaborative Network to evaluate whether postherpetic neuralgia after herpes zoster is associated with an increased risk of incident dementia. Adults aged 40 to 120 years with incident herpes zoster between 1 October 2015 and 31 December 2024 are identified using diagnostic codes. Postherpetic neuralgia is defined by International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes B02.22 or B02.29 recorded between 90 and 365 days after the index herpes zoster date, and comparators have no such codes between 90 and 365 days after index. The primary analysis uses 1:1 propensity score matching and a 365-day landmark design, including only individuals alive and free of dementia at the landmark. Time-to-event analyses estimate hazard ratios for incident dementia and related outcomes.