Life sciences · Interventional Study
ClinicalTrials.gov · September 25, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT05913713). This is a study registration, not published results. Lead sponsor: University of Florida. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 37 participants (ACTUAL). Conditions: Breast Cancer. Interventions: BEHAVIORAL: 12-week Intervention Period; BEHAVIORAL: 12-week Observation Period. Primary outcome measures: Change in brachial FMD , Baseline, Following a 12-week intervention period, Following a 12-week observation period; Change in cardiac function (global longitudinal strain) , Baseline, Following a 12-week intervention period, Following a 12-week observation period; Percent completed vs. planned exercise frequency , Throughout the 12 weeks of supervised home-based exercise training; Percent completed vs. planned exercise duration , Throughout the 12 weeks of supervised home-based exercise training; Percent completed vs. planned exercise intensity , Throughout the 12 weeks of supervised home-based exercise training; Number of participants who experience adverse events as defined by most recent CTCAE throughout the exercise intervention , Throughout the 12 weeks of supervised home-based exercise training. Brief summary: Chemotherapy is an effective breast cancer treatment, which helped to increase the 5-year survival rate to approximately 95%. However, breast cancer survivors have a higher risk of cardiovascular disease (CVD) due to chemotherapy than adults without cancer. Cardiovascular rehabilitation can be an effective strategy to decrease the incidence of CVD and its risk factors in this population. The proposed study may help to examine the effect and durability of a novel high-intensity interval training compared to moderate-intensity continuous training on cardiovascular rehabilitation in breast cancer survivors.