Life sciences · Phase 2 Trial
ClinicalTrials.gov · October 16, 2026
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Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT06450873). This is a study registration, not published results. Lead sponsor: Mayo Clinic. Recruitment status: RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 40 participants (ESTIMATED). Conditions: Estrogen Receptor-Positive Breast Carcinoma, HER2-Negative Breast Carcinoma. Interventions: DRUG: Coriolus Versicolor Extract; OTHER: Questionnaire Administration. Primary outcome measures: Change in Ki-67 , Baseline; at the time of surgery. Brief summary: This phase II trial tests how well turkey tail mushroom (TTM) works in treating post-menopausal women with HER2-negative, estrogen receptor (ER)-positive breast cancer undergoing surgery. TTM is a common mushroom. In traditional Chinese medicine, it is used for enhancing function and removing toxins, as well as for cancer, hepatitis, and infections. There is previous evidence of significant tumor shrinkage occurring in the 2-month window between diagnosis and surgery in women who have taken TTM. Giving TTM may be effective in treating post-menopausal women with HER2-negative, ER-positive breast cancer undergoing surgery.