Life sciences · Interventional Study
ClinicalTrials.gov · October 22, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06854367). This is a study registration, not published results. Lead sponsor: Centre for Addiction and Mental Health. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 280 participants (ESTIMATED). Conditions: Late Life Depression (LLD), Depression - Major Depressive Disorder, Depressive Disorder, Treatment-Resistant, Mood Disorders. Interventions: DEVICE: TBS. Primary outcome measures: Depression severity , 6 weeks. Brief summary: The purpose of this trial is to compare the treatment efficacy (improvement in depressive symptoms) of accelerated TBS protocol (where participants receive multiple TBS treatments daily) to conventional TBS protocol (where participants receive a single TBS treatment daily) in late life depression. In addition, the study also aims to determine if specific patterns of stimulation are more or less effective. To do this, all participants will receive active treatments, but some of the participants in this study will receive accelerated TBS and some will receive once daily TBS.