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Life sciences · Journal article
International Journal of Drug Delivery Technology · October 15, 2026
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Cervical cancer remains one of the leading causes of cancer-related mortality among women worldwide, particularly in developing countries.Although conventional treatments such as chemotherapy, radiotherapy, and surgery are available, their effectiveness is often limited by systemic toxicity, multidrug resistance, and poor targeting of cancer cells.Natural phytoconstituents such as Curcumin and Silymarin have demonstrated significant anticancer, antioxidant, and anti-inflammatory activities against various malignancies, including cervical cancer.Curcumin inhibits multiple signaling pathways involved in tumor growth, angiogenesis, and metastasis, while Silymarin suppresses oxidative stress and promotes apoptosis in cancer cells.However, their therapeutic application is restricted due to poor aqueous solubility, low permeability, rapid metabolism, and limited bioavailability.The present study focuses on the development of a targeted Curcumin-Silymarin nanosuspension to enhance solubility, cellular uptake, and therapeutic efficacy against cervical cancer.The nanosuspension is prepared using nanoprecipitation or high-speed homogenization techniques with stabilizers such as polyvinyl pyrrolidone (PVP), poloxamer, and Tween 80 to ensure particle stability and prevent aggregation.The formulation is optimized by varying process parameters and evaluated for particle size, polydispersity index, zeta potential, morphology, entrapment efficiency, drug content, saturation solubility, and in vitro drug release.Anticancer activity is assessed using HeLa cervical cancer cell lines through cytotoxicity, apoptosis, cellular uptake, and cell viability studies.The nanosized formulation is expected to improve drug dissolution, enhance intracellular delivery, and provide synergistic anticancer effects.These findings suggest that Curcumin-Silymarin nanosuspension may serve as a promising targeted nanocarrier system for effective cervical cancer therapy.